Coordination of Zn2+ (and Cd2+) by Prokaryotic Metallothionein
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چکیده
منابع مشابه
Cytosolic Distribution of Cd2+, Cu2+, and Zn2+ Among Metallothionein-Like Proteins in Lobster Hepatopancreas
Zinc and Cu metabolism in crustacea changes dramatically during the molt cycle. Metallothionein (MT) and MT-like proteins are implicated in the handling of both metal ions as well as in the detoxification of Cd. Distribution of Cd2 / Cu / and Zn2 / in cytosol and among MT-like species has been determined. Lobsters were treated to induce MT as in mammals with dexamethasone (dex) or stress from t...
متن کاملDomain-specificity of Cd2+ and Zn2+ binding to rabbit liver metallothionein 2. Metal ion mobility in the formation of Cd4-metallothionein alpha-fragment.
The yield of the alpha-fragment of rabbit liver metallothionein 2 was used to test the domain-specificity and mobility of Cd2+ and Zn2+ when bound to metallothionein. Increasing molar ratios of Cd2+ were added to either Zn7-metallothionein or the metal-ion-free apo-metallothionein. The enzyme subtilisin was used to digest those parts of the peptide chain that were not bound to Cd2+. Analysis of...
متن کاملExposure of human proximal tubule cells to cd2+, zn2+, and Cu2+ induces metallothionein protein accumulation but not metallothionein isoform 2 mRNA.
The organization of the human metallothionein (MT) gene family is more complex than the commonly used mouse and rat models. The human MTs are encoded by a family of genes consisting of 10 functional and 7 nonfunctional MT isoforms. One objective of this study was to determine if the accumulation of MT protein in cultures of human proximal tubule (HPT) cells exposed to metals is similar to that ...
متن کاملAxial bis(terpyridoxy)phosphorus(V) porphyrin: modulation of PET and EET by Zn2+ or Cd2+ ions.
A novel phosphorus(V) porphyrin bearing two ptp[4'-(4-phenyloxy)-2,2'ratio6',2''-terpyridine] groups was prepared and modulation of the intramolecular PET (lambda(ex)= 566 nm) and PET --> EET (lambda(ex)= 300 nm) processes was studied from ptp to phosphorus(V) porphyrin by Zn2+ or Cd2+ ions.
متن کاملMetallothionein Zn2+- and Cu2+-clusters from first-principles calculations.
Detailed electronic structures of Zn(II) and Cu(II) clusters from metallothioneins (MT) have been obtained using density functional theory (DFT), in order to investigate how oxidative stress-caused Cu(II) intermediates affect Zn-binding to MT and cooperatively lead to Cu(I)MT. The inferred accuracy is ∼0.02-0.03 Å for metal-thiolate bond lengths for the models that are the most realistic MT mod...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1998
ISSN: 0021-9258
DOI: 10.1074/jbc.273.36.22957